TABLE 2.
Measures of the functional observational and neurobehavioral test battery
| FOB measurea |
|---|
| Autonomic |
| Lacrimation (h) |
| Salivation (h) |
| Urination (o.f.) |
| Defecation (o.f.) |
| Vocalizations (h.c., o.f.) |
| Activity |
| Rearing (o.f.) |
| Motor activity counts (s.m.a.) |
| Home cage posture (h.c.) |
| Speed (o.f.) |
| Path length (o.f.) |
| Resting time (o.f.) |
| Excitability |
| Ease of removal (h) |
| Handling reactivity (h) |
| Arousal (o.f.) |
| Clonic movements (h.c., o.f.) |
| Tonic movements (h.c., o.f.) |
| Palpebral closure (h.c., h) |
| Motor function |
| Gait score (o.f.) |
| Righting reflex (s.r.) |
| Beam balance and traverse (b.t.) |
| Sensorimotor |
| Tail pinch response (s.r.) |
| Click response (s.r.) |
| Touch response (s.r.) |
| Approach response (s.r.) |
| Physiological and other measures |
| Body wt (h) |
| Piloerection (h) |
| Bizarre behavior (h.c., o.f.) |
| Stereotypy (h.c., o.f.) |
a
Measures are organized according to domains of neurological function and location within testing schedule. Measures shown in boldface were changed by mefloquine treatment. Abbreviations in parentheses refer to the point in the observational battery at which endpoints were measured. h.c., home cage observations; h, handling observations; o.f., open field tests; s.r., stimulus reactivity measurements; b.t., beam testing; s.m.a., spontaneous motor activity measurements.