TABLE 3.

Clinical signs and weight change in six rats administered 765 mg/kg mefloquine

Time (h)	Wt change for rat no.						Decline in relative wt (% predose ± SE)
	1	2	3	4	5	6
0	None	None	None	None	None	None	100 ± 2.0
24	None	None	None	None	None	None	99 ± 2.7
48	Mild	Mild	None	None	Mild	Severea	96 ± 2.2
72	Severea	Mild	Severea	Mild	Mild		91 ± 2.9b

^aDeath was the likely outcome for rats with severe clinical symptoms or weight loss. These rats were euthanized.

^bSignificantly different from predose values.