TABLE 4.
Histopathological changes observed with mefloquine-treated rats
| Nucleus | Degree of neurodegenerationa for treatment group receiving:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Vb | V | V | Mefloquine dose (mg/kg)
|
||||||
| 187 | 187 | 187 | 765 | 765 | 765 | ||||
| Gracilis | − | − | − | + | ++ | +/− | +++ | +++ | ++++ |
| Cuneatus | − | − | − | − | +/− | − | ++ | + | ++ |
| Solitary tract | − | − | − | + | ++ | + | ++ | ++ | ++ |
a
Neurodegeneration was scored using a relative, semiquantitative scale: no damage (−), borderline damage (+/−), mild damage (+), moderate damage (++), marked damage (+++), or severe damage (++++).
b
V, vehicle control.