FIG. 5.

Inhibition of polyprotein processing in HCV replicon cells. Replicon cells were treated with SCH 503034 (0 to 100 μM, 1:3 serial dilution). Cells were harvested at various time points as indicated, and cell lysates were analyzed by Western blot for NS5A as described in Materials and Methods. The position of the high-molecular-weight processing intermediate (possibly NS3-NS5B) is indicated by an arrow. Additional processing intermediates, detected at 6 h posttreatment, are indicated by a bracket.