TABLE 1.
Interaction of fluconazole and BBR against 40 clinical isolates of C. albicans resistant to fluconazole by checkerboard microdilution assaya
| Parameter | MIC50 (μg/ml)
|
MIC80 (μg/ml)
|
||
|---|---|---|---|---|
| Median | Range | Median | Range | |
| Fluconazole | 8 | 0.5->64 | 128 | ≥64 |
| BBR | 64 | ≥32 | 64 | >32 |
| Fluconazole + BBRb | 0.5/1 | ≤0.125-1/1-4 | 1/2 | ≤0.125-2/1-8 |
| FIC index | 0.148 | 0.033-1.063 | 0.034 | 0.017-0.127 |
a
When analyzed with MIC50s, synergism was observed in 32 of 40 isolates (80%) and indifference was observed in 8 of the 40 isolates (20%); at MIC80, synergy was observed in all of the isolates.
b
MICs in combination are expressed as [fluconazole]/[BBR]. High off-scale MICs were converted to the next highest concentrations.