TABLE 2.
MICs for and detected mutations in H. influenzae strains
| Strain | MIC (μg/ml) of:
|
Mutation(s)
|
|||||
|---|---|---|---|---|---|---|---|
| Telithromycin | Azithromycin | Clarithromycin | L4 | L22 | 23S rRNA
|
||
| Domain II | Domain V | ||||||
| MJ17 | 2 | 0.5 | 8 | A69S | G845C, U855C, C894A, A925G | ||
| MJ22 | 2 | 1 | 8 | K61Q | G884U, C894A | ||
| 1999-112-023 | 4 | 8 | >32 | G65C | A654G | ||
| MJ13 | 4 | 1 | 8 | K61Q | A633G, A654G | ||
| MJ3 | 4 | 8 | >32 | D139G | G884U, C894A | G2160U | |
| 1999-130-053 | 8 | 8 | >32 | G65D | A654G, INS G877 | ||
| HH506 | 8 | 4 | >32 | A654G | |||
| MJ4 | 16 | 16 | >32 | K61Q | C612U, A654G | ||
| MJ5 | 16 | 8 | >32 | T64K | G91D | A654G, INS A602, INS A624 | C2164G |
| MJ9 | 16 | 4 | 32 | DEL 81S | A654G, G884U, C894A | ||
| MJ16 | 32 | 16 | >32 | INS 91 KG | C635G | ||
| MJ19 | 32 | 8 | 32 | K61Q | G884U, C894A | ||
| MJ20 | 32 | 32 | >32 | DEL M82 | G884U, C894A | ||
| MJ6 | 32 | 32 | >32 | T64K | C612U, A654G | ||
| 1999-130-001 | 32 | 8 | >32 | DEL 96ILK | G884U, C894A | ||
| HI100 | 64 | 64 | >32 | K61Q | A654G, G884U, C894A | ||
| MJ7 | 64 | 16 | >32 | DEL 95RI | G884U, C894A | ||
| 1999-130-044 | >64 | >32 | >32 | INS 88RAKG | A654G | ||
| MJ1 | >64 | >32 | >32 | DEL 95RI | C885U, C894A | GGA2160-2UAU | |
| MJ10 | >64 | >32 | >32 | A654G | A2058G, G2160U | ||
| MJ11 | >64 | >32 | >32 | T64K | G91D | G884U, C894A | |
| MJ2 | >64 | 32 | >32 | T64K | G91D | A654G | C2164G |
| MJ24 | >64 | >32 | >32 | T64K | G91D | A654G | |
| MJ8 | >64 | 32 | >32 | T64K | G91D | A654G | C2164G |