TABLE 1.
Susceptibility in vitro to posaconazole and other antifungal agents of yeast species
| Species | No. of isolates | Susceptibility (MIC,a μg/ml) of indicated agent to yeast
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amphotericin B
|
Flucytosine
|
Fluconazole
|
Itraconazole
|
Voriconazole
|
Posaconazole
|
Caspofungin
|
|||||||||
| MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | ||
| Candida species | |||||||||||||||
| Candida albicans | 940 | 0.06 | 0.12 | 0.12 | 0.50 | 0.12 | 0.25 | 0.02 | 0.03 | 0.02 | 0.02 | 0.02 | 0.02 | 0.12 | 0.25 |
| Candida parapsilosis | 387 | 0.12 | 0.25 | 0.12 | 0.25 | 0.50 | 0.50 | 0.03 | 0.06 | 0.02 | 0.03 | 0.02 | 0.03 | 0.50 | 1.0 |
| Candida tropicalis | 202 | 0.12 | 0.25 | 0.12 | 0.25 | 0.25 | 0.50 | 0.02 | 0.06 | 0.02 | 0.06 | 0.02 | 0.06 | 0.12 | 1.0 |
| Candida glabrata | 244 | 0.12 | 0.25 | 0.12 | 0.25 | 4.0 | 16.0 | 0.25 | 1.0 | 0.25 | 1.0 | 0.25 | 1.0 | 0.12 | 0.25 |
| Candida krusei | 94 | 0.25 | 0.50 | 4.0 | 4.0 | 32.0 | 64.0 | 0.25 | 0.25 | 0.25 | 0.50 | 0.12 | 0.25 | 0.25 | 0.50 |
| Candida guilliermondii | 52 | 0.12 | 0.25 | 0.12 | 0.25 | 4.0 | 8.0 | 0.25 | 0.50 | 0.06 | 0.12 | 0.06 | 0.12 | 1.0 | 16.0 |
| Candida lusitaniae | 21 | 0.06 | 0.12 | 0.12 | 0.25 | 0.12 | 0.50 | 0.02 | 0.06 | 0.02 | 0.02 | 0.02 | 0.02 | 0.50 | 1.0 |
| Candida kefyr | 13 | 0.12 | 0.25 | 1.0 | >64.0 | 0.25 | 1.0 | 0.03 | 0.03 | 0.02 | 0.02 | 0.02 | 0.03 | 0.06 | 0.12 |
| Candida famata | 10 | 0.50 | 1.0 | 0.25 | 64.0 | 16.0 | >64.0 | 0.50 | >8.0 | 0.12 | >8.0 | 0.12 | >8.0 | 8.0 | >16.0 |
| Candida pelliculosa | 10 | 0.06 | 0.50 | 0.12 | 16.0 | 8.0 | >64.0 | 0.50 | >8.0 | 0.25 | >8.0 | 1.0 | >8.0 | 0.25 | 0.50 |
| Other Candida spp.b | 24 | 0.12 | 2.0 | 0.25 | 16.0 | 8.0 | >64.0 | 0.06 | 4.0 | 0.06 | 8.0 | 0.03 | 8.0 | 0.50 | 16.0 |
| Other Ascomycota yeasts | |||||||||||||||
| Dipodascus capitatus | 25 | 0.12 | 8.0 | 0.12 | 16.0 | 8.0 | 16.0 | 0.12 | 0.25 | 0.12 | 0.50 | 0.12 | 0.25 | 16.0 | >16.0 |
| Saccharomyces cerevisiae | 15 | 0.12 | 0.25 | 0.12 | 8.0 | 2.0 | 4.0 | 0.25 | 0.50 | 0.06 | 0.12 | 0.12 | 0.50 | 0.50 | 1.0 |
| Yarrowia lipolytica | 13 | 0.50 | 0.50 | 16.0 | >64.0 | 8.0 | 16.0 | 0.25 | 2.0 | 0.12 | 2.0 | 0.12 | 0.50 | >16.0 | >16.0 |
| Galactomyces geotrichum | 12 | 0.25 | 0.25 | 0.12 | 1.0 | 16.0 | 16.0 | 1.0 | 8.0 | 1.0 | 4.0 | 0.50 | 1.0 | >16.0 | >16.0 |
| Basidiomycota yeasts | |||||||||||||||
| C. neoformans var. neoformans | 183 | 0.06 | 0.25 | 8.0 | 16.0 | 16.0 | 16.0 | 0.25 | 0.50 | 0.25 | 0.50 | 0.25 | 0.50 | >16.0 | >16.0 |
| C. neoformans var. gattii | 28 | 0.12 | 0.12 | 1.0 | 2.0 | 16.0 | 16.0 | 0.50 | 1.0 | 0.50 | 1.0 | 0.25 | 0.50 | >16.0 | >16.0 |
| Trichosporon asahii | 17 | 2.0 | >8.0 | 16.0 | >64.0 | 8.0 | 32.0 | 1.0 | >8.0 | 0.50 | >8.0 | 0.25 | >8.0 | >16.0 | >16.0 |
| Rhodotorula mucilaginosa | 24 | 0.12 | 0.25 | 0.25 | 0.25 | 16.0 | >64.0 | 4.0 | >8.0 | 4.0 | >8.0 | 2.0 | >8.0 | >16.0 | >16.0 |
| Trichosporon inkin | 10 | 0.25 | 0.50 | >64.0 | >64.0 | 2.0 | 4.0 | 0.12 | 0.50 | 0.25 | 2.0 | 0.12 | 0.25 | >16.0 | >16.0 |
| Other Basidiomycota yeastsc | 32 | 0.25 | 16.0 | 16.0 | >64.0 | 16.0 | >64.0 | 0.25 | >8.0 | 0.25 | >8.0 | 0.12 | >8.0 | >16.0 | >16.0 |
a
MIC50 (MIC causing inhibition of 50% of isolates) and MIC90 (MIC causing inhibition of 90% of isolates) values were calculated for those species with 10 or more isolates.
b
Other Candida species include species with less than 10 isolates: Candida pintolopesii (4 isolates), Candida haemulonii (4), Candida dubliniensis (4), Candida colliculosa (3), Candida rugosa (3), Candida sake (2), and Candida norvegensis (2).
c
Other Basidiomycota yeasts include species with less than 10 isolates: Trichosporon ovoides (7 isolates), Trichosporon dermatis (7), Cryptococcus albidus (6), Rhodotorula glutinis (5), Cryptococcus laurentii (3), other Trichosporon spp. (4).