TABLE 2.
Susceptibility in vitro to posaconazole and other antifungal agents of filamentous fungi included in the study
| Species | No. of isolates | Susceptibility (MIC,a μg/ml) of indicated agent to fungi
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Amphotericin B
|
Itraconazole
|
Voriconazole
|
Posaconazole
|
||||||
| MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | ||
| Aspergillus spp. | |||||||||
| Aspergillus fumigatus | 375 | 0.25 | 0.50 | 0.25 | 0.50 | 0.25 | 1.0 | 0.06 | 0.25 |
| Aspergillus flavus | 110 | 1.0 | 2.0 | 0.25 | 1.0 | 0.50 | 2.0 | 0.12 | 0.50 |
| Aspergillus terreus | 74 | 1.0 | 8.0 | 0.25 | 0.50 | 0.50 | 1.0 | 0.06 | 0.25 |
| Aspergillus niger | 55 | 0.25 | 0.25 | 0.50 | 4.0 | 1.0 | 1.0 | 0.25 | 0.50 |
| Aspergillus nidulans | 29 | 0.50 | 2.0 | 0.25 | >8.0 | 0.25 | >8.0 | 0.12 | >8.0 |
| Aspergillus sydowii | 21 | 0.50 | 1.0 | 0.50 | 1.0 | 0.50 | 2.0 | 0.06 | 0.50 |
| Aspergillus versicolor | 13 | 0.50 | 2.0 | 0.50 | 1.0 | 1.0 | 2.0 | 0.25 | 0.50 |
| Other Aspergillus spp. | 20 | 0.50 | >16.0 | 0.50 | >8.0 | 0.50 | >8.0 | 0.12 | >8.0 |
| Other hyaline fungi | |||||||||
| Scedosporium apiospermum | 65 | 4.0 | >16.0 | 8.0 | >8.0 | 1.0 | 4.0 | 1.0 | 8.0 |
| Penicillium spp. | 45 | 0.50 | 4.0 | 0.50 | 8.0 | 2.0 | 8.0 | 0.25 | 2.0 |
| Scopulariopsis brevicaulis | 19 | 4.0 | 16.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 |
| Fusarium solani | 18 | 1.0 | 4.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 |
| Fusarium oxysporum | 15 | 0.50 | 1.0 | >8.0 | >8.0 | 4.0 | >8.0 | 4.0 | >8.0 |
| Fusarium verticillioides | 11 | 2.0 | >16.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 |
| Paecilomyces lilacinus | 11 | >16.0 | >16.0 | 8.0 | >8.0 | 0.25 | 8.0 | 0.25 | 0.50 |
| Paecilomyces variotii | 10 | 0.12 | 1.0 | 0.06 | 0.25 | 1.0 | 4.0 | 0.03 | 0.50 |
| Acremonium spp. | 10 | 2.0 | 16.0 | 8.0 | >8.0 | 2.0 | 4.0 | 1.0 | 4.0 |
| Other hyaline fungib | 27 | 0.25 | 4.0 | 0.50 | >8.0 | 1.0 | >8.0 | 0.25 | >8.0 |
| Black fungi | |||||||||
| Scedosporium prolificans | 37 | 16.0 | >32.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 | >8.0 |
| Alternaria spp. | 11 | 0.25 | 0.50 | 0.25 | >8.0 | 1.0 | >8.0 | 0.12 | >8.0 |
| Other black fungic | 15 | 0.12 | 0.50 | 0.25 | >8.0 | 0.12 | >8.0 | 0.06 | >8.0 |
| Mucorales | |||||||||
| Rhizopus oryzae | 15 | 0.50 | 2.0 | >8.0 | >8.0 | >8.0 | >8.0 | 0.50 | 8.0 |
| Other Mucorales speciesd | 16 | 0.12 | 2.0 | 1.0 | >8.0 | 8.0 | >8.0 | 1.0 | >8.0 |
MIC50 (MIC causing inhibition of 50% of isolates) and MIC90 (MIC causing inhibition of 90% of isolates) values were calculated for those species with 10 or more isolates.
Other hyaline fungi include species with less than 10 isolates: Arthrographis kalrae (5 isolates), Trichoderma spp. (4), Scopulariopsis spp. (2), Arthrographis cuboidea (2), Cylindrocarpon spp. (2), Hormographiella verticillata (2), Chrysosporium spp. (2), Arthrinium phaeospermum (2), Phialemonium curvatum (2), Paecilomyces fumosoroseus (1), Chrysonilia sitophila (1), Beauveria bassiana (1), and Myceliophthora thermophila (1).
Other black fungi include species with less than 10 isolates: Rhinocladiella aquaspersa (3 isolates), Aureobasidium pullulans (2), Exophiala jeanselmei (1), Exophiala dermatitidis (1), Cladosporium spp. (1), Cladophialophora bantiana (1), Curvularia lunata (1), Nattrassia mangiferae (1), Ochroconis gallopava (1), Scytalidium hyalinum (1), Scytalidium infestans (1), and Lecythophora spp. (1).
Other Mucorales include species with less than 10 isolates: Rhizopus microsporus (5 isolates), Absidia corymbifera (4), Mucor circinelloides (2), Rhizomucor pusillus (2), Rhizomucor miehei (1), Rhizomucor variabilis (1), and Cunninghamella bertholletiae (1).