TABLE 1.
Ciprofloxacin and tobramycin PK/PD parameters obtained in the mouse model of lung infection by P. aeruginosa strains PAO1 and PAOΔmutS
| Treatment | Dose (mg/kg) | Dosing interval (h) | fCmax (mg/liter) | ft1/2 (h) | fAUC (mg · h/liter) | MICa (μg/ml) | fAUC/MICa ratio | fCmax/MICa ratio |
|---|---|---|---|---|---|---|---|---|
| Ciprofloxacin | 20 | 6 | 5.75 | 1.30 | 48.16 | 0.125 | 385 | 60 |
| Tobramycin | 10 | 6 | 19.07 | 0.55 | 42.96 | 1 | 43 | 19 |
a
Ciprofloxacin and tobramycin MICs determined by Etest were identical for PAO1 and PAOΔmutS, and therefore, the same PK/PD parameters (fAUC/MIC and fCmax/MIC) were obtained for both strains.