FIG. 4.

Patterns of Bvg-regulated gene expression in B. pertussis GMT-1. Data are centered within each experiment. Results obtained with NA modulation and phase-locked strain analysis are shown from Bvg⁺ (left) to Bvg⁻ (right), whereas the phase shift experiment is depicted from Bvg⁻ (left) to Bvg⁺ (right). Rows correspond to array probes, and columns correspond to experiments. +, phase-locked Bvg⁺; i, phase-locked Bvgⁱ; −, phase-locked Bvg⁻. Red, increased transcript abundance; green, decreased transcript abundance; black, no significant change in transcript abundance; gray, no data. NA concentrations (millimolar) and time elapsed after shift (minutes) are indicated along the bottom. The four major gene expression classes, with some representative loci, and the Bvg-independent NA-induced class are indicated on the right. Purple arrowhead, bipA. The set of genes represented by the gray bar on the right passed filtering criteria but showed no discernible pattern.