TABLE 3.

Involvement of PA5471 in antimicrobial resistance in P. aeruginosa

Strain	Relevant phenotype	MIC (μg/ml)a
		Ami	Gen	Kan	Neo	Par	Spc	Str	Tob	Cef	Cam	Car	Ery	Nor	Tet
K2162	WT	128	256	1,024	512	>2,048	1,024	256	128	64	256	512	512	1	16
K2435	PA5471−	—	32	—	—	256	128	32	—	—	—	512	—	—	—
K2436	PA5471−	—	32	—	—	256	128	32	—	—	—	512	—	—	—
K2418	PA5471−	32	64	512	256	512	128	64	64	64	256	512	512	1	16
K767	WT	4	8	128	64	256	512	32	4	16	32	32	512	0.5	16
K2413	PA5471−	2	4	64	64	64	128	8	4	16	32	32	128	0.5	8
K1525	MexXY−	2	4	64	32	32	64	4	4	16	32	32	64	0.5	8
K2414	PA5471− MexXY−	2	4	64	32	32	64	4	4	16	32	32	64	0.5	8
K2413(pUCP20T)	PA5471−	2	4	64	64	64	128	8	4	8	32	—	128	0.5	8
K2413(pYM010)	PA5471+	8	8	128	128	512	512	64	4	8	32	—	512	1	8
K2413(pMMB190)	PA5471−	2	4	64	64	64	128	8	4	8	32	—	128	0.5	8
K2413(pYM004)	PA5471− MexXY++	8	8	128	128	512	512	64	4	8	32	—	512	1	8
K2417(pUCP20T)	PA5471− PA5470−	2	2	64	64	64	128	8	2	16	32	—	128	0.5	8
K2417(pYM010)	PA5471+ PA5470−	8	8	256	128	512	1,024	64	4	16	32	—	512	1	16

^aAmi, amikacin; Gen, gentamicin; Kan, kanamycin; Neo, neomycin; Par, paromomycin; Spc, spectinomycin; Str, streptomycin; Tob, tobramycin; Cef, cefotaxime; Cam, chloramphenicol; Car, carbenicillin; Ery, erythromycin; Nor, norfloxacin; Tet, tetracycline. —, not determined.