TABLE 1.
Regulation of cytokines on exposure to different human β-defensins
| Defensin | Day | Cytokine (array position)a
|
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-1β (C2) | IL-5 (G2) | IL-6 (H2) | IL-8 (J2) | IL-10 (K2) | IL-16 (C7) | EGF (I4) | ENA-78 (G1) | GRO (J1) | HGF (I6) | IGFBP-3 (A7) | MCP-1 (E3) | MCP-2 (F3) | MDC (I3) | MIP-1-β (K3) | MIP-1-δ (A4) | OPG (B8) | RANTES (B4) | ||
| hBD-1 | 1 | − | − | U+ | U+ | U+ | − | U+ | U− | U− | − | U+ | U+ | − | − | U+ | − | − | − |
| 6 | − | D+ | − | − | − | − | − | U+ | − | − | D+ | − | − | − | − | U+ | D+ | − | |
| hBD-2 | 1 | U+ | − | U++ | U− | U++ | − | U+ | U+ | U− | − | U+ | U++ | − | − | U− | − | − | U− |
| 6 | U++ | D+ | U++ | − | − | − | D+ | U++ | U+ | D+ | − | − | U− | D+ | − | − | − | D− | |
| hBD-3 | 1 | − | − | − | U− | − | − | − | − | − | − | U+ | U− | − | − | − | − | − | − |
| 6 | − | − | − | − | D+ | − | − | − | U++ | D− | − | − | − | − | − | D+ | U+ | ||
a
U, up-regulated; D, down-regulated; +, moderate effect; ++, strong effect. A minus (−) with U or D indicates a weak effect; a minus alone indicates no effect.