TABLE 4.
Effect of treatment with (N)-MCT in BALB/c mice infected intranasally with VV or CV
Strain and treatmenta (mg/kg) | Mortality
|
MDDb | P value | ||
---|---|---|---|---|---|
No. dead/total no. | % | P value | |||
VV strain IHD | |||||
0.4% CMC | 15/15 | 100 | 7.6 | ||
CDV | |||||
15 | 0/15 | 0 | <0.001 | ||
(N)-MCT | |||||
50 | 0/15 | 0 | <0.001 | ||
16.7 | 0/15 | 0 | <0.001 | ||
5.6 | 3/15 | 20 | <0.001 | 8.7 | <0.05 |
VV strain WR | |||||
0.4% CMC | 15/15 | 100 | 7.9 | ||
CDV | |||||
15 | 0/15 | 0 | <0.001 | ||
(N)-MCT | |||||
50 | 0/15 | 0 | <0.001 | ||
16.7 | 2/15 | 13 | <0.001 | 7.5 | NSc |
5.6 | 12/15 | 80 | NS | 8.2 | NS |
CV strain Brighton | |||||
0.4% CMC | 15/15 | 100 | 9.6 | ||
CDV | |||||
15 | 0/15 | 0 | <0.001 | ||
(N)-MCT | |||||
50 | 2/15 | 13 | <0.001 | 7.5 | NS |
16.7 | 3/15 | 20 | <0.001 | 13.3 | 0.01 |
5.6 | 6/15 | 40 | <0.001 | 14.0 | 0.05 |
(N)-MCT was prepared in 0.4% carboxymethyl cellulose and delivered i.p. twice daily in 0.1-ml doses. CDV was prepared in sterile saline and given i.p. once daily in 0.1-ml doses. All animals were treated for 5 days beginning 24 h postinfection.
MDD, mean day of death.
NS, not significant.