TABLE 1.
Median inhibitory concentrations of study drugs in field isolates from Gabona
| Drug (no. of isolates) | IC50 | IC90 | IC99 |
|---|---|---|---|
| OZ277 (38) | 0.47 (0.13-2.23) | 1.29 (0.26-5.00) | 3.73 (0.37-6.84) |
| Artesunate (43) | 0.96 (0.20-5.95) | 2.47 (0.33-29.9) | 5.76 (0.57-49.0) |
| Chloroquine (43)b | 113 (12.4-332) | 241 (20.2-737) | 544 (40.2-967) |
| Mefloquine (44) | 1.94 (0.24-21.2) | 4.02 (0.27-48.8) | 10.1 (0.30-124) |
a
Results are shown in nanomolar (median [range]).
b
All isolates are beyond the threshold level of resistance (1 μmol/liter corresponds to 30 nM in our assay conditions).