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. 2006 Apr;50(4):1376–1383. doi: 10.1128/AAC.50.4.1376-1383.2006

FIG. 4.

FIG. 4.

Relationships of the PPI-0903 total drug level, %T>MIC, peak/MIC, and 24-h AUC/MIC for S. pneumoniae ATCC 10813 (a), S. aureus 33591 (b), and K. pneumoniae (c) with the change in log10 CFU/thigh after 24 h of therapy. Each symbol represents the mean data from two mice (four thighs). The dashed horizontal line represents the burden of organisms at the start of therapy. Data above the line represent growth, and data below the line represent killing. R2 is the coefficient of determination.