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Relationship between the PPI-0903 free-drug %T>MIC and efficacy against five S. pneumoniae (a), four S. aureus (b), and four gram-negative bacilli (c). Each symbol represents the mean data for two mice (four thighs). R2 is the coefficient of determination. The dashed horizontal line represents the burden of organisms at the start of therapy. Data below the line represent killing, and data above the line represent growth.
