TABLE 3.

PPP-0903 in vivo activity in murine thigh and lung infection models against multiple organisms

Organism	MIC (mg/liter)	Static		1 log kill		2 log kill
		Dose (mg/kg/24 h)	%T>MIC	Dose (mg/kg/24 h)	%T>MIC	Dose (mg/kg/24 h)	%T>MIC
S. pneumoniae 10813 (neutropenic)	0.008	0.32	34	0.45	37	0.61	43
S. pneumoniae 10813 (normal)		0.20	29	0.29	33	0.41	36
S. pneumoniae 1199	0.06	1.8	35	3.42	44	6.03	51
S. pneumoniae 1329	0.06	1.15	30	2.04	37	3.72	45
S. pneumoniae 1325	0.06	6.5	52	8.46	53	10.65	60
S. pneumoniae 1293	0.12	14.3	50	22.2	59	34.0	64
Mean ± SD			39 ± 9		43 ± 9		50 ± 10
S. aureus 25923	0.12	3.75	36	7.23	44	14.8	51
S. aureus 29213	0.25	2.57	30	7.63	37	26.9	56
MRSA	0.50	9.88	21	22.0	34	64.1	50
S. aureus 33591	1.0	6.19	15	9.98	18	18.0	23
Mean ± SD			26 ± 8		33 ± 9		45 ± 13
E. coli 25922	1.0	56	32	89.2	44	154	50
E. coli 1894-1	2.0	234	37	1,040	57
K. pneumoniae 43816 (thigh)	2.0	22	15	51	24	992	58
K. pneumoniae 43816 (lung)		38	22	117	35	808	53
K. pneumoniae 216	2.0	125	34	500	44
Mean ± SD			28 ± 9		41 ± 11		54 ± 3