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. 2006 Apr;50(4):1238–1244. doi: 10.1128/AAC.50.4.1238-1244.2006

FIG. 2.

FIG. 2.

Effect of AMB formulation on disease progression in L. major-infected BALB/c mice. Groups of mice were infected with 1 × 106 LV39 L. major promastigotes and treated at 24 h, 48 h, 10 days, 20 days, 30 days, and 40 days with PBS (control), 5 mg/kg AMB in AmBisome, or 5 mg/kg AMB in AMB-ND. Data are derived from a single experiment (n = 1). (A) Effect of AMB formulation on footpad lesion size in L. major-infected BALB/c mice. Footpad lesion size was measured at the indicated time points. Values plotted are the means ± standard deviations of 2 to 14 measurements. (B) Effect of AMB formulation on parasite numbers per footpad in L. major-infected BALB/c mice. Parasite numbers per footpad were determined as described in Materials and Methods from samples obtained at the indicated time points. Values reported are the means ± 95% confidence limits of parasite numbers based on limiting-dilution analysis as described in Material and Methods.