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(A) Effect of time of addition on the antiviral activity of a 40-base Randomer 1. Various control compounds (see Results) and Randomer 1 were added to cultured cells at various times during (<2 h) or after (>2 h) infection with HIV-1. All compounds were used at IC99. (B) Inhibitory activity of PS-ONs in attachment and fusion. A 40-base Randomer 1 PS-ON was tested in an attachment-fusion assay against both X4- and R5-tropic HIV-1 strains.
