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. 2006 Apr;50(4):1393–1401. doi: 10.1128/AAC.50.4.1393-1401.2006

FIG. 4.

FIG. 4.

PS-ON size and phosphorothioation dependence on inhibition of 6-HB formation by FN-PAGE. (A) Different-size analogues of Randomer 1, 2, and 3 ONs (200 μM) were added to the N36 peptide (40 μM) before the addition of the FITC-C34 peptide (40 μM). A size-dependent inhibition was observed with Randomer 1 and 2 PS-ONs, but no significant inhibition was observed with Randomer 3 ONs of any size. (B) Dose response of the inhibition of the N36/FITC-C34 complex (both at 40 μM) by increasing concentrations of 40-base Randomer 2 or 3 ONs. For simplicity only the region of the gel displaying the 6-HB complex is shown in panels A and B.