TABLE 3.

Inoculum changes in single- and mixed-pathogen models of MRSA and VRE

Antimicrobial agent(s)	Change in bacterial density (log10 CFU/ml) over 48 h in model of:
	MRSA alone	VRE alone	MRSA in presence of VRE	VRE in presence of MRSA
None (control)	+1.57	+1.91	+0.08a	+1.51
Arbekacin	−2.54b	+1.05	−4.43b,c	−3.06b
Daptomycin	−2.99b	−3.06b	−4.20b	−2.05b
Linezolid	−1.79b	−1.87b	−2.59b	−2.05b
Tigecycline	−1.82b	−1.06b	−3.38b,c	−2.35b
Daptomycin + arbekacin			−4.26b,c	−2.49b
Linezolid + arbekacin			−4.27b,c	−1.35b
Tigecycline + arbekacin			−4.24b,c	+0.06d

^aP = 0.02 compared to VRE growth control in a mixed-pathogen model.

^bP ≤ 0.05 compared to respective growth control.

^cP ≤ 0.05 compared to antimicrobial and MRSA alone.

^dAntagonism observed.