TABLE 2.
MICs of micafungin and other drugs for S. cerevisiae strains hyperexpressing fungal transporters and for C. albicans strainsa
| Strain | MIC (μg/ml) of:
|
|||||
|---|---|---|---|---|---|---|
| MCF | CSF | FLC | ITC | VRC | NYT | |
| S. cerevisiae | ||||||
| AD1-8u− | 0.125 | 1 | 0.5 | 0.031 | 0.063 | 2 |
| AD/CaMDR1 | 0.125 | 1 | 60 | 0.031 | 0.5 | 2 |
| AD/CaCDR1 A | 0.125 | 1 | 200 | >32 | 16 | 2 |
| AD/CaCDR1 B | 0.250 | 1 | 300 | >32 | 16 | 2 |
| AD/CaCDR2 A | 0.125 | 1 | 80 | >32 | 4 | 2 |
| AD/CaCDR2 B | 0.125 | 2 | 160 | >32 | 4 | 2 |
| AD/CgCDR1 | 0.125 | 1 | 300 | >32 | 4 | 4 |
| AD/CnMDR1 | 0.125 | 1 | 5 | >32 | 0.063 | 2 |
| C. albicans | ||||||
| ATCC 10261 | 0.0078 | 0.25 | 0.5 | 0.063 | 0.063 | 8 |
| TIMM3163 | 0.0156 | 0.25 | 32 | 0.5 | 0.5 | 8 |
| TL1 | 0.0078 | 0.5 | 1 | 0.125 | 0.063 | 8 |
| TL3 | 0.0156 | 0.5 | 32 | 0.5 | 0.5 | 8 |
a
Cells were incubated in CSM (pH 7.0) at 30°C for 48 h for S. cerevisiae and at 35°C for 24 h for C. albicans strains. C. albicans CDR1, CDR2, and MDR1 were from ATCC 10261. Three separate experiments with triplicate determinations each gave identical end points.