Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1983;15(Suppl 2):263S–268S. doi: 10.1111/j.1365-2125.1983.tb05874.x

The pharmacology of mianserin—an update

R J Marshall
PMCID: PMC1427877  PMID: 6130779

Full text

PDF
263S

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banerjee S. P., Kung L. S., Riggi S. J., Chanda S. K. Development of beta-adrenergic receptor subsensitivity by antidepressants. Nature. 1977 Aug 4;268(5619):455–456. doi: 10.1038/268455a0. [DOI] [PubMed] [Google Scholar]
  2. Baumann P. A., Maître L. Blockade of presynaptic alpha-receptors and of amine uptake in the rat brain by the antidepressant mianserine. Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):31–37. doi: 10.1007/BF00505077. [DOI] [PubMed] [Google Scholar]
  3. Brown J., Doxey J. C., Handley S. Effects of alpha-adrenoceptor agonists and antagonists and of antidepressant drugs on pre- and postsynaptic alpha-adrenoceptors. Eur J Pharmacol. 1980 Oct 3;67(1):33–40. doi: 10.1016/0014-2999(80)90005-9. [DOI] [PubMed] [Google Scholar]
  4. Cerrito F., Raiteri M. Supersensitivity of central noradrenergic presynaptic autoreceptors following chronic treatment with the antidepressant mianserin. Eur J Pharmacol. 1981 Mar 26;70(3):425–426. doi: 10.1016/0014-2999(81)90176-x. [DOI] [PubMed] [Google Scholar]
  5. Doggrell S. A. Effect of mianserin on noradrenergic transmission in the rat anococcygeus muscle. Br J Pharmacol. 1980 Feb;68(2):241–250. doi: 10.1111/j.1476-5381.1980.tb10413.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Doxey J. C., Everitt J., Metcalf G. Mianserin--an analysis of its peripheral autonomic actions. Eur J Pharmacol. 1978 Sep 1;51(1):1–10. doi: 10.1016/0014-2999(78)90055-9. [DOI] [PubMed] [Google Scholar]
  7. Fludder J. M., Leonard B. E. Chronic effects of mianserin on noradrenaline metabolism in the rat brain: evidence for a pre-synaptic alpha-adrenolytic action in vivo. Psychopharmacology (Berl) 1979 Sep;64(3):329–332. doi: 10.1007/BF00427519. [DOI] [PubMed] [Google Scholar]
  8. Goodlet I., Mireylees S. E., Sugrue M. F. Effects of mianserin, a new antidepressant, on the in vitro and in vivo uptake of monoamines. Br J Pharmacol. 1977 Oct;61(2):307–313. doi: 10.1111/j.1476-5381.1977.tb08420.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Green J. P., Maayani S. Tricyclic antidepressant drugs block histamine H2 receptor in brain. Nature. 1977 Sep 8;269(5624):163–165. doi: 10.1038/269163a0. [DOI] [PubMed] [Google Scholar]
  10. Hall H., Ogren S. O. Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol. 1981 Mar 26;70(3):393–407. doi: 10.1016/0014-2999(81)90172-2. [DOI] [PubMed] [Google Scholar]
  11. Kanof P. D., Greengard P. Brain histamine receptors as targets for antidepressant drugs. Nature. 1978 Mar 23;272(5651):329–333. doi: 10.1038/272329a0. [DOI] [PubMed] [Google Scholar]
  12. Langer S. Z. Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. Br J Pharmacol. 1977 Aug;60(4):481–497. doi: 10.1111/j.1476-5381.1977.tb07526.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Maggi A., U'Prichard D. C., Enna S. J. Differential effects of antidepressant treatment on brain monoaminergic receptors. Eur J Pharmacol. 1980 Jan 25;61(2):91–98. doi: 10.1016/0014-2999(80)90152-1. [DOI] [PubMed] [Google Scholar]
  14. Mishra R., Janowsky A., Sulser F. Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding. Neuropharmacology. 1980 Oct;19(10):983–987. doi: 10.1016/0028-3908(80)90009-x. [DOI] [PubMed] [Google Scholar]
  15. Nickolson V. J., Wieringa J. H. Presynaptic alpha-block and inhibition of noradrenaline and 5-hydroxytryptamine reuptake by a series of compounds related to mianserin. J Pharm Pharmacol. 1981 Dec;33(12):760–766. doi: 10.1111/j.2042-7158.1981.tb13927.x. [DOI] [PubMed] [Google Scholar]
  16. Olpe H. R., Schellenberg A., Steinmann M. W. Differential actions of mianserin and iprindole on the sensitivity of cortical neurons to noradrenaline: effect of chronic treatment. Eur J Pharmacol. 1981 Jul 10;72(4):381–385. doi: 10.1016/0014-2999(81)90581-1. [DOI] [PubMed] [Google Scholar]
  17. Peet M., Behagel H. Mianserin: a decade of scientific development. Br J Clin Pharmacol. 1978;5 (Suppl 1):5S–9S. [PMC free article] [PubMed] [Google Scholar]
  18. Raiteri M., Angelini F., Bertollini A. Comparative study of the effects of mianserin, a tetracyclic antidepressant, and of imipramine on uptake and release of neurotransmitters in synaptosomes. J Pharm Pharmacol. 1976 Jun;28(6):483–488. doi: 10.1111/j.2042-7158.1976.tb02770.x. [DOI] [PubMed] [Google Scholar]
  19. Schwartz J. C. Histaminergic mechanisms in brain. Annu Rev Pharmacol Toxicol. 1977;17:325–339. doi: 10.1146/annurev.pa.17.040177.001545. [DOI] [PubMed] [Google Scholar]
  20. Schwartz J. C. Minireview: histamine receptors in brain. Life Sci. 1979 Sep 11;25(11):895–911. doi: 10.1016/0024-3205(79)90495-8. [DOI] [PubMed] [Google Scholar]
  21. Sellinger-Barnette M. M., Mendels J., Frazer A. The effect of psychoactive drugs on beta-adrenergic receptor binding sites in rat brain. Neuropharmacology. 1980 May;19(5):447–454. doi: 10.1016/0028-3908(80)90052-0. [DOI] [PubMed] [Google Scholar]
  22. Sugrue M. F. Changes in rat brain monoamine turnover following chronic antidepressant administration. Life Sci. 1980 Feb 11;26(6):423–429. doi: 10.1016/0024-3205(80)90160-5. [DOI] [PubMed] [Google Scholar]
  23. Sugrue M. F. Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content. Life Sci. 1981 Jan 26;28(4):377–384. doi: 10.1016/0024-3205(81)90082-5. [DOI] [PubMed] [Google Scholar]
  24. Tang S. W., Seeman P. Effect of antidepressant drugs on serotonergic and adrenergic receptors. Naunyn Schmiedebergs Arch Pharmacol. 1980 Apr;311(3):255–261. doi: 10.1007/BF00569405. [DOI] [PubMed] [Google Scholar]
  25. U'Prichard D. C., Greenberg D. A., Sheehan P. P., Snyder S. H. Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain. Science. 1978 Jan 13;199(4325):197–198. doi: 10.1126/science.202024. [DOI] [PubMed] [Google Scholar]
  26. Vargaftig B. B., Coignet J. L., de Vos C. J., Grijsen H., Bonta I. L. Mianserin hydrochloride: peripheral and central effects in relation to antagonism against 5-hydroxytryptamine and tryptamine. Eur J Pharmacol. 1971 Nov-Dec;16(3):336–346. doi: 10.1016/0014-2999(71)90036-7. [DOI] [PubMed] [Google Scholar]
  27. Vetulani J., Stawarz R. J., Dingell J. V., Sulser F. A possible common mechanism of action of antidepressant treatments: reduction in the sensitivity of the noradrenergic cyclic AMP gererating system in the rat limbic forebrain. Naunyn Schmiedebergs Arch Pharmacol. 1976 May;293(2):109–114. doi: 10.1007/BF00499215. [DOI] [PubMed] [Google Scholar]
  28. Vetulani J., Sulser F. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature. 1975 Oct 9;257(5526):495–496. doi: 10.1038/257495a0. [DOI] [PubMed] [Google Scholar]
  29. Waldmeier P. C. Noradrenergic transmission in depression: under- or overfunction? Pharmacopsychiatria. 1981 Jan;14(1 Suppl):3–9. doi: 10.1055/s-2007-1019557. [DOI] [PubMed] [Google Scholar]
  30. Whitaker P. M., Cross A. J. 3H-Mianserin binding in calf caudate: possible involvement of serotonin receptors in anti-depressant drug action. Biochem Pharmacol. 1980 Oct 1;29(19):2709–2712. doi: 10.1016/0006-2952(80)90095-7. [DOI] [PubMed] [Google Scholar]
  31. Wilson J. A., Read J. R., Boyd E. J., Wormsley K. G. Inhibition of pentagastrin-stimulated and overnight gastric secretion by mianserin. Br J Clin Pharmacol. 1983;15 (Suppl 2):329S–333S. doi: 10.1111/j.1365-2125.1983.tb05882.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Wolfe B. B., Harden T. K., Sporn J. R., Molinoff P. B. Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants. J Pharmacol Exp Ther. 1978 Nov;207(2):446–457. [PubMed] [Google Scholar]
  33. van Riezen H. Different central effects of the 5-HT antagonists mianserine and cyproheptadine. Arch Int Pharmacodyn Ther. 1972 Aug;198(2):256–269. [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES