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. 1983 Dec;16(6):599–608. doi: 10.1111/j.1365-2125.1983.tb02228.x

Exercise-induced increments in plasma levels of propranolol and noradrenaline.

G A Hurwitz, J G Webb, T Walle, S A Bai, H B Daniell, L Gourley, C Boyd Loadholt, T E Gaffney
PMCID: PMC1428364  PMID: 6661342

Abstract

Exercise-induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise-induced increments of 13 +/- 4% at 4 h after the last dose, 18 +/- 7% at 9 h and 41 +/- 5% at 16 h. Exercise-induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise-induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action.

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Selected References

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