TABLE 3.
Mouse colonization densities for H. pylori strain SS1 and mutantsa
| Strain or mutant | Infected animals/total | CFU/g stomach ± SD |
|---|---|---|
| Mock infected (saline) | 0/5 | 0 |
| SS1 WT | 5/5 | 3.87 × 107 ± 1.26 × 107 |
| SS1 tlpB | 3/5 | 81 ± 61 |
| SS1 tlpC | 5/5 | 2.59 × 107 ± 1.1 × 107 |
| SS1 tlpD | 5/5 | 3.15 × 107 ± 1.4 × 107 |
| G27 | 2/5 | 81 ± 74 |
| SS1 WTb | 4/4 | 3.3 × 105 ± 2.1 × 105 |
| SS1 tlpB/tlpB+b | 4/4 | 4.6 × 104 ± 2.0 × 104 |
a
Five animals each were infected with SS1 and tlp mutants and 3 weeks post infection, bacterial load was determined (CFU/g stomach) as described in the text.
b
Four C57BL/6J mice each were infected with SS1 WT and complemented SS1 ΔtlpB mutant (SS1 ΔtlpB/tlpB+). The colonization efficiency of SS1 for IL-12-deficient mice is ca. 100-fold greater than for C57BL/6J mice as previously described (13).