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Alignment of PhoR2 with PhoR3 (A), and PhoP2 with PhoP3 (B). Identical amino acids are boxed in black, and functionally similar amino acids are boxed in gray. ▾, putative cleavage site of the signal peptide in both kinases; ♦, amino acids of the transmembrane domain; *, amino acids that are conserved in response regulators; , amino acids that constitute the two helixes of the helix-loop-helix motif.
