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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1979 Mar;7(3):223–229. doi: 10.1111/j.1365-2125.1979.tb00926.x

Methods of the assessment of the effect of drugs on liver blood flow in man.

E E Ohnhaus
PMCID: PMC1429496  PMID: 427000

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Selected References

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  1. BRADLEY S. E., INGELFINGER F. J., BRADLEY G. P. Hepatic circulation in cirrhosis of the liver. Circulation. 1952 Mar;5(3):419–429. doi: 10.1161/01.cir.5.3.419. [DOI] [PubMed] [Google Scholar]
  2. Bircher J., Blankart R., Halpern A., Häcki W., Laissue J., Preisig R. Criteria for assessment of functional impairment in patients with cirrhosis of the liver. Eur J Clin Invest. 1973 Jan;3(1):72–85. doi: 10.1111/j.1365-2362.1973.tb00332.x. [DOI] [PubMed] [Google Scholar]
  3. Bradley S. E., Ingelfinger F. J., Bradley G. P., Curry J. J. THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN. J Clin Invest. 1945 Nov;24(6):890–897. doi: 10.1172/JCI101676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Branch R. A., Shand D. G., Wilkinson G. R., Nies A. S. Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow. J Clin Invest. 1974 Apr;53(4):1101–1107. doi: 10.1172/JCI107647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CAESAR J., SHALDON S., CHIANDUSSI L., GUEVARA L., SHERLOCK S. The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci. 1961 Aug;21:43–57. [PubMed] [Google Scholar]
  6. CONN H. L., Jr Equilibrium distribution of radioxenon in tissue: xenon-hemoglobin association curve. J Appl Physiol. 1961 Nov;16:1065–1070. doi: 10.1152/jappl.1961.16.6.1065. [DOI] [PubMed] [Google Scholar]
  7. DOBSON E. L., JONES H. B. The behavior of intravenously injected particulate material; its rate of disappearance from the blood stream as a measure of liver blood flow. Acta Med Scand Suppl. 1952;273:1–71. [PubMed] [Google Scholar]
  8. DOBSON E. L., WARNER G. F., FINNEY C. R., JOHNSTON M. E. The measurement of liver circulation by means of the colloid disappearance rate. I. Liver blood flow in normal young men. Circulation. 1953 May;7(5):690–695. doi: 10.1161/01.cir.7.5.690. [DOI] [PubMed] [Google Scholar]
  9. Darle N. Xenon 133 clearance and liver blood flow. An experimental study in the cat. Acta Chir Scand. 1970;407:1–64. [PubMed] [Google Scholar]
  10. Dietze G., Wicklmayr M., Czempiel H., Henftling H. G., Hepp K. D., Mehnert H. Zur analyse der lebervenösen 133Xenon-Clearance nach Zufuhr des Gases durch Inhalation. Klin Wochenschr. 1975 Jul 1;53(13):639–640. doi: 10.1007/BF01469686. [DOI] [PubMed] [Google Scholar]
  11. GRAYSON J. Internal calorimetry in the determination of thermal conductivity and blood flow. J Physiol. 1952 Sep;118(1):54–72. doi: 10.1113/jphysiol.1952.sp004772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GRAYSON J., JOHNSON D. H. The effect of adrenaline and noradrenaline on the liver blood flow. J Physiol. 1953 Apr 28;120(1-2):73–94. doi: 10.1113/jphysiol.1953.sp004874. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GRAYSON J., KINNEAR T. Observations on temperature, blood flow and heat production in the human liver in relation to environment and to glucose and insulin administration. Clin Sci. 1962 Feb;22:125–140. [PubMed] [Google Scholar]
  14. GRAYSON J., MENDEL D. The role of the spleen and the hepatic artery in the regulation of liver blood flow. J Physiol. 1957 Apr 3;136(1):60–79. doi: 10.1113/jphysiol.1957.sp005743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Gram L. F., Christiansen J. First-pass metabolism of imipramine in man. Clin Pharmacol Ther. 1975 May;17(5):555–563. doi: 10.1002/cpt1975175555. [DOI] [PubMed] [Google Scholar]
  16. Gram L. F., Overo K. F. First-pass metabolism of nortriptyline in man. Clin Pharmacol Ther. 1975 Sep;18(3):305–314. doi: 10.1002/cpt1975183305. [DOI] [PubMed] [Google Scholar]
  17. Greenway C. V., Stark R. D. Hepatic vascular bed. Physiol Rev. 1971 Jan;51(1):23–65. doi: 10.1152/physrev.1971.51.1.23. [DOI] [PubMed] [Google Scholar]
  18. HENSEL H., RUEF J., GOLENHOFEN K. Fortlaufende Registrierung der Muskeldurchblutung am Menschen mit einer Calorimetersonde. Pflugers Arch. 1954;259(4):267–280. doi: 10.1007/BF00363606. [DOI] [PubMed] [Google Scholar]
  19. Huet P. M., Marleau D., Lavoie P., Viallet A. Extraction of 125I-albumin microaggregates from portal blood. An index of functional portal blood supply in cirrhotics. Gastroenterology. 1976 Jan;70(1):74–81. [PubMed] [Google Scholar]
  20. KETTERER S. G., WIEGAND B. D., RAPAPORT E. Hepatic uptake and biliary excretion of indocyanine green and its use in estimation of hepatic blood flow in dogs. Am J Physiol. 1960 Sep;199:481–484. doi: 10.1152/ajplegacy.1960.199.3.481. [DOI] [PubMed] [Google Scholar]
  21. Künzli H. F., Fridrich R. Zur Bestimmung der relativen portalen Leberdurchblutung mit Xenon-133 nach Kanülierung der Umbilikalvene. Dtsch Med Wochenschr. 1972 Aug 4;97(31):1159–1161. doi: 10.1055/s-0028-1107519. [DOI] [PubMed] [Google Scholar]
  22. LEVY M. L., PALAZZI H. M., NARDI G. L., BUNKER J. P. Hepatic blood flow variations during surgical anesthesia in man measured by radioactive colloid. Surg Gynecol Obstet. 1961 Mar;112:289–294. [PubMed] [Google Scholar]
  23. LORBER S. H., OPPENHEIMER M. J., SHAY H., LYNCH P., SIPLET H. Enterohepatic circulation of bromsulphalein: intraduodenal, intraportal and intravenous dye administration in dogs. Am J Physiol. 1953 May;173(2):259–264. doi: 10.1152/ajplegacy.1953.173.2.259. [DOI] [PubMed] [Google Scholar]
  24. Nies A. S., Shand D. G., Wilkinson G. R. Altered hepatic blood flow and drug disposition. Clin Pharmacokinet. 1976;1(2):135–155. doi: 10.2165/00003088-197601020-00005. [DOI] [PubMed] [Google Scholar]
  25. Ohnhaus E. E., Emons E., Breckenridge A. Long term liver blood flow measurements in rats under physiological conditions. Pflugers Arch. 1971;323(2):182–186. doi: 10.1007/BF00586448. [DOI] [PubMed] [Google Scholar]
  26. Ohnhaus E. E., Locher J. T. Liver blood flow and blood volume following chronic phenobarbitone administration. Eur J Pharmacol. 1975 Apr;31(2):161–165. doi: 10.1016/0014-2999(75)90036-9. [DOI] [PubMed] [Google Scholar]
  27. Ohnhaus E. E., Thorgeirsson S. S., Davies D. S., Breckenridge A. Changes in liver blood flow during enzyme induction. Biochem Pharmacol. 1971 Oct;20(10):2561–2570. doi: 10.1016/0006-2952(71)90164-x. [DOI] [PubMed] [Google Scholar]
  28. Pichlmayr I. Leberdurchblutung, Herzminutenvolumen und andere Kreislaufgrössen unter Einwirkung verschiedener Narkosemittel beim Hund. Z Kreislaufforsch. 1969 Jul;58(7):759–773. [PubMed] [Google Scholar]
  29. REEMSTSMA K., HOTTINGER G. C., DEGRAFF A. C., Jr, CREECH O., Jr The estimation of hepatic blood flow using indocyanine green. Surg Gynecol Obstet. 1960 Mar;110:353–356. [PubMed] [Google Scholar]
  30. REES J. R., REDDING V. J., ASHFIELD R. HEPATIC BLOOD-FLOW MEASUREMENT WITH XENON 133. EVIDENCE FOR SEPARATE HEPATIC-ARTERIAL AND PORTAL-VENOUS PATHWAYS. Lancet. 1964 Sep 12;2(7359):562–563. doi: 10.1016/s0140-6736(64)90623-3. [DOI] [PubMed] [Google Scholar]
  31. REYNOLDS T. B., REDEKER A. G., GELLER H. M. Wedged hepatic venous pressure; a clinical evaluation. Am J Med. 1957 Mar;22(3):341–350. doi: 10.1016/0002-9343(57)90090-6. [DOI] [PubMed] [Google Scholar]
  32. SAPIRSTEIN L. A. Fractionation of the cardiac output of rats with isotopic potassium. Circ Res. 1956 Nov;4(6):689–692. doi: 10.1161/01.res.4.6.689. [DOI] [PubMed] [Google Scholar]
  33. SAPIRSTEIN L. A., REININGER E. J. Catheter induced error in hepatic venous sampling. Circ Res. 1956 Jul;4(4):493–498. doi: 10.1161/01.res.4.4.493. [DOI] [PubMed] [Google Scholar]
  34. SAPIRSTEIN L. A. Regional blood flow by fractional distribution of indicators. Am J Physiol. 1958 Apr;193(1):161–168. doi: 10.1152/ajplegacy.1958.193.1.161. [DOI] [PubMed] [Google Scholar]
  35. SCHENK W. G., Jr, McDONALD J. C., McDONALD K., DRAPANAS T. Direct measurement of hepatic blood flow in surgical patients: with related observations on hepatic flow dynamics in experimental animals. Ann Surg. 1962 Sep;156:463–471. doi: 10.1097/00000658-196209000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. SCHENK W. G., Jr, McDONALD J. C., McDONALD K., DRAPANAS T. Direct measurement of hepatic blood flow in surgical patients: with related observations on hepatic flow dynamics in experimental animals. Ann Surg. 1962 Sep;156:463–471. doi: 10.1097/00000658-196209000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. SIMPSON A. M., EZROW L., SAPIRSTEIN L. A. Measurement of plasma volume with rose bengal (tetraiodo-tetrabrom-fluorescene). Am J Physiol. 1954 May;177(2):319–324. doi: 10.1152/ajplegacy.1954.177.2.319. [DOI] [PubMed] [Google Scholar]
  38. Schmitz-Feuerhake I., Huchzermeyer H., Reblin T. Determination of the specific blood flow of the liver by inhalation of radioactive rare gases. Acta Hepatogastroenterol (Stuttg) 1975 Jun;22(3):150–158. [PubMed] [Google Scholar]
  39. Sellers A. F., Dobson A. Some applications and limitations of electromagnetic blood flow measurements in chronic animal preparations. Gastroenterology. 1967 Feb;52(2):374–379. [PubMed] [Google Scholar]
  40. Strandell T., Erwald R., Kulling K. G., Lundbergh P., Marions O., Wiechel K. L. Measurement of dual hepatic blood flow in awake patients. J Appl Physiol. 1973 Nov;35(5):755–761. doi: 10.1152/jappl.1973.35.5.755. [DOI] [PubMed] [Google Scholar]
  41. TOBIAS C. A., JONES H. B. The uptake and elimination of krypton and other inert gases by the human body. J Clin Invest. 1949 Nov;28(6 Pt 1):1375–1385. doi: 10.1172/JCI102203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. TORRANCE H. B., GOWENLOCK A. H. Radioactive colloidal clearance techniques to measure liver blood flow in man. Clin Sci. 1962 Jun;22:413–423. [PubMed] [Google Scholar]
  43. VETTER H., FALKNER R., NEUMAYR A. The disappearance rate of colloidal radio-gold from the circulation and its application to the estimation, of liver blood flow in normal and cirrhotic subjects. J Clin Invest. 1954 Dec;33(12):1594–1602. doi: 10.1172/JCI103039. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Veall N., Mallett B. L. Regional cerebral blood flow determination by 133-Xe inhalation and external recording: the effect of arterial recirculation. Clin Sci. 1966 Jun;30(3):353–369. [PubMed] [Google Scholar]
  45. WALK L. Roentgenologic determination of the liver volume. Acta radiol. 1961 Jan;55:49–56. doi: 10.3109/00016926109173816. [DOI] [PubMed] [Google Scholar]
  46. Wagner H. N., Jr, Rhodes B. A., Sasaki Y., Ryan J. P. Studies of the circulation with radioactive microspheres. Invest Radiol. 1969 Nov-Dec;4(6):374–386. doi: 10.1097/00004424-196911000-00004. [DOI] [PubMed] [Google Scholar]
  47. Wilkinson G. R. Pharmacokinetics of drug disposition: hemodynamic considerations. Annu Rev Pharmacol. 1975;15:11–27. doi: 10.1146/annurev.pa.15.040175.000303. [DOI] [PubMed] [Google Scholar]
  48. Wilkinson G. R., Shand D. G. Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther. 1975 Oct;18(4):377–390. doi: 10.1002/cpt1975184377. [DOI] [PubMed] [Google Scholar]
  49. Wyatt D. G. Baseline errors in cuff electromagnetic flowmeters. Med Biol Eng. 1966 Jan;4(1):17–45. doi: 10.1007/BF02474784. [DOI] [PubMed] [Google Scholar]
  50. de Valois J. C., Smith J., Peperkamp J. P. A computer program for the determination of cerebral blood flow using the Kr-85 or Xe-133 intra-arterial injection method. Int J Biomed Comput. 1970 Jan;1(1):49–60. doi: 10.1016/0020-7101(70)90015-2. [DOI] [PubMed] [Google Scholar]

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