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. 1979;7(Suppl 1):109S–112S. doi: 10.1111/j.1365-2125.1979.tb04675.x

A clinical view of clobazam

H H Wieck, L Blaha, B Heerklotz
PMCID: PMC1429506  PMID: 35188

Abstract

1 The results so far published in the literature, together with our own results, show that in clobazam (Frisium) we have a daytime tranquillizer which is comparable to the newest benzodiazepine derivatives.

2 It is particularly indicated in disorders of the sleeping-waking rhythm, and sometimes also in psychovegetative disorders associated with epilepsy.

3 Its tranquillizing profile of action, the low incidence of side-effects and the absence of interactions with other drugs mean that its applications are varied, not only in neuropsychiatry but also in other medical disciplines.

4 The fact that therapeutic doses do not seem to impair driving ability or render patients incapable of carrying on their profession, means that it is suitable for the treatment of outpatients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barzaghi F., Fournex R., Mantegazza P. Pharmacological and toxicological properties of clobazam (1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine), a new psychotherapeutic agent. Arzneimittelforschung. 1973 May;23(5):683–686. [PubMed] [Google Scholar]
  2. Borland R. G., Nicholson A. N. Immediate effects on human performance of a 1,5-genzodiazepine (clobazam) compared with the 1,4-benzodiazepines, chlordiazepoxide hydrochloride and diazepam. Br J Clin Pharmacol. 1975 Jun;2(3):215–221. doi: 10.1111/j.1365-2125.1975.tb01578.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Freche C. Etude d'un anxiolytique Clobazam en O.R.L. dans les manifestations psychosomatiques pharyngées. Sem Hop Ther. 1975 Apr;51(4):261–263. [PubMed] [Google Scholar]
  4. Hindmarch I., Hanks G. W., Hewett A. J. Clobazam, a 1,5-benzodiazepine, and car-driving ability. Br J Clin Pharmacol. 1977 Oct;4(5):573–578. doi: 10.1111/j.1365-2125.1977.tb00788.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Laudano O., Peralta M., Lujan L., Aparicio N., Moizeszowicz J. Effect of a new benzodiazepine derivate, clobazam, in anxious patients with gastrointestinal disorders. J Clin Pharmacol. 1977 Jul;17(7):441–446. doi: 10.1002/j.1552-4604.1977.tb04627.x. [DOI] [PubMed] [Google Scholar]
  6. Nicholson A. N., Stone B. M., Clarke C. H. Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man. Br J Clin Pharmacol. 1977 Oct;4(5):567–572. doi: 10.1111/j.1365-2125.1977.tb00787.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Radmayr E., Koeppen D. Clobazam (Frisium) in der täglichen Praxis Offene Halbjahresstudie zur Wirksamkeit und Verträglichkeit. MMW Munch Med Wochenschr. 1977 Dec 16;119(50):1623–1626. [PubMed] [Google Scholar]
  8. Skupin G., Franzke H. G. Tranxilium 20 (Dikalium-chlorazepat) als 24-Stunden-Tranquilizer. Med Welt. 1975 May 9;26(19):956–959. [PubMed] [Google Scholar]
  9. Wieck H. H. Mode of action of modern tranquillizers from the benzodiazepine group: a clinical view [proceedings]. Br J Clin Pharmacol. 1979;7 (Suppl 1):107S–108S. doi: 10.1111/j.1365-2125.1979.tb04674.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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