FIG. 1.

Amino acid sequence and primary structure model of EFsec and SPB2 with predicted NLS (blue), NES (pink), and NoLS (green) domains highlighted. (A) Mouse EFsec sequence and model, with the elongation factor domain in light gray and the SBP2-interaction domain in dark gray. (B) Rat SBP2 sequence and model, with transactivation domain in light gray and SECIS RNA binding domain in dark gray. Two RRM motifs previously identified in SBP2 are underlined. Gray bars in the cartoon schematics indicate the functional domains mapped previously (for a review, see reference 39 for EFsec and reference 14 for SBP2).