FIG. 2.

Gadd34-null mice have hypersplenism and decreased numbers of mature erythroid precursors. (A) Direct spleen weights of 4-month-old wild-type and Gadd34-null mice. Data are plotted as means for six animals from each genotype ± standard errors of the mean (SEM) (P = 0.0072). (B) Average mature (black bars) and immature (white bars) erythroid precursors in the spleen calculated (mature = CD71^lo divided by CD71^hi + CD71^lo) for six animals from each genotype ± SEM. (C) Gadd34-null spleens have increased numbers of nucleated cells in the red pulp. Sections of spleen from wild-type (left) and Gadd34-null (right) mice were stained with HE. Magnification, ×20.