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Myosin VI is a novel target gene of p53. (A) Myosin VI is induced by p53 in a time-dependent manner. (B) Induction of myosin VI by wild-type and various mutated forms of p53. (C) Myosin VI is induced by DNA damage in a p53-dependent manner. RKO and LS174T were either untreated (−) or treated (+) with 300 nM camptothecin for 24 h. Northern blots were probed with 32P-labeled cDNA for myosin VI, p21, and/or GAPDH.
