FIG. 8.

Loss of Mnt predisposes to lymphomagenesis. (A) Survival curves of lck-Cre-Mnt^flox/+ and lck-Cre-Mnt^flox/flox mice. Mice showing obvious tumors or that became moribund were euthanized and examined. (B) Radiograph showing a large malignant tumor in a 12-month-old lck-Cre-Mnt^flox/flox mouse. (C) Top parts, histopathologic analysis showing kidney and lung tumors (arrows). The normal lung morphology of lck-Cre-Mnt^flox/+ mice is shown in the inset. Lower parts, immunohistochemical analysis showing strong CD3 staining specifically in tumor tissue (arrows).