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. 2006 Mar;26(6):2146–2159. doi: 10.1128/MCB.26.6.2146-2159.2006

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Copyright © 2006, American Society for Microbiology

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FIG. 5. — Human C1 is crucial for extended lifespan and telomere maintenance. (A) TRAP analysis of BJT cells transduced with retroviruses expressing MMH, HHM, mTERT-hC1, hTERT-mC1, mTERT-hC2, hTERT-mC2, hTERT, or mTERT. (B) C1 domain of hTERT is required, but not sufficient for extended lifespan. Serial passage of cells in panel A is shown. (C and D) Telomeres shorten then stabilize in immortal hTERT-mC2-BJT cells over 150 population doublings by TRF Southern blot analysis (mTERT-BJT and hTERT-BJT shown for comparison).