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Bright shuttles between the nucleus and cytoplasm. HeLa cells were transiently transfected with myc-Bright wild type or the NES-deficient G532A mutant and then fused with NIH 3T3 cells. Bright proteins were detected by immunostaining the resulting heterokaryons with anti-myc monoclonal antibody. myc-hnRNP A1 was previously shown to be a shuttling protein, whereas myc-hnRNP C1 served as a nucleus-only control (44).
