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. 2006 Apr 6;116(5):1410–1424. doi: 10.1172/JCI27607

Figure 8. Cysteamine increases blood levels of BDNF in rodents and in a primate HD model.

Figure 8

(A) Data (ANOVA, F 2,27 =17.13; P < 0.0001) revealed that the amount of BDNF in serum of mice treated with cystamine (post-hoc Fisher’s test, P < 0.0001) or with cysteamine (post-hoc Fisher’s test, P < 0.0001) was significantly increased. (B) The blood level of BDNF (ANOVA, F 3,50 =17.22; P < 0.0001) was reduced in Hdh109Q/109Q mice compared with wild-type littermates (post-hoc Fisher’s test, P = 0.0001) and rescued by cysteamine. The amount of BDNF in the serum of wild-type mice (post-hoc Fisher’s test, P = 0.0099) and Hdh109Q/109Q mice (post-hoc Fisher’s test, P = 0.0010) was increased upon cysteamine treatment. (C) There was an increase of BDNF in serum of 4 cysteamine-treated rats (ANOVA, F 10,64 = 9.29; P < 0.0001) after 45 minutes (post-hoc Fisher’s test, P < 0.0001) and 60 minutes (post-hoc Fisher’s test, P < 0.0001). (D) BDNF levels were reduced in the blood of 3NP-treated monkeys (Student’s t test, t[27] = 3.05; P = 0.005). **P < 0.01 and #P < 0.001. Data are from 4 controls and three 3NP-treated monkeys. (E and F) Blood BDNF levels were increased in HD monkeys injected with cysteamine. (E) Representative results for 1 monkey are shown. (F) Graph represents the results for the 2 injected monkeys. Error bars represent SEM.