Figure 8.

DHBA induces apoptosis and reduces parasitic burden. A: DHBA reduces both splenic and hepatic parasitic burden in infected golden hamsters. Experiments with intramuscular (IM) and oral (○) administration of DHBA were performed in triplicate and representative data from 1 set of these experiments for spleen (▪) and liver (□) are expressed as mean ±SD. B: Micrographs of Giemsa-stained splenic and hepatic smears of L. donovani–infected golden hamsters after treatment with DHBA. Infected hamsters were treated both orally (○) and intramuscularly (IM) with either phosphate-buffered saline or 10 mg/kg body weight of DHBA.