Figure 7.
Inosine prolongs survival (A) and insulin content (B) of syngeneic islet grafts transplanted into female diabetic NOD mice. Diabetes recurred in all vehicle-treated (□) mice (7 of 7) by day 14 after islet transplantation, whereas 50% (5 of 10) mice treated with inosine 200 mg kg−1d−1(▪) were normoglycemic at 70 d after islet transplantation. Grafts from inosine-treated mice which were normoglycemic (▪) had significantly more insulin as compared with vehicle-treated grafts removed from both diabetic (□) and normoglycemic mice (▨).