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. 2003 Sep-Dec;9(9-12):226–234. doi: 10.2119/2003-00042.rodrigues

Figure 2.

Figure 2

TUDCA inhibits Aβ-induced cytochrome c release in rat cortical neurons. Cells were incubated with either vehicle (control), 25 μM Aβ fragment 25–35, 100 μM TUDCA, or a combination of Aβ plus TUDCA for 24 h as described in Materials and Methods. Mitochondrial (top) and cytosolic (bottom) proteins were processed for Western blot analysis. Following SDS-PAGE and transfer, the nitrocellulose membranes were incubated with a monoclonal antibody to cytochrome c (Cyt c). Histograms are mean ±SEM for at least 3 different experiments. §P < 0.05 and *P < 0.01 from control; ‡P < 0.05 from Aβ.