Table 1.
Up-regulation of specific gene expression in human vascular endothelial cells treated with interleukin-4
| Gene symbol | NCBI accession nr | Fold change | P value | Description |
|---|---|---|---|---|
| Adhesion molecules | ||||
| VCAM1 | NM_001078 | 21.7 | <0.001 | Vascular cell adhesion molecule 1 |
| CSPG2 | D32039 | 5.4 | 0.006 | Chondroitin sulfate proteoglycan 2 |
| SELE | NM_000450 | 4.3 | <0.001 | E-selectin |
| AIM1 | U83115 | 4.1 | <0.001 | Absent in melanoma 1 |
| AGC1 | X17406 | 3.2 | 0.002 | Aggrecan 1 |
| PCDH7 | NM_002589 | 2.7 | <0.001 | BH-protocadherin |
| FCN3 | NM_003665 | 2.2 | 0.023 | Ficolin (collage/fibrinogen domain) 3 |
| FAT | NM_005245 | 2.0 | 0.007 | FAT tumor suppressor homolog 1 |
| Chemokines and cytokines | ||||
| CCL2 | S69738 | 8.2 | <0.001 | Monocyte chemoattractant protein-1 |
| IL6 | NM_000600 | 2.0 | 0.003 | Interleukin-6 |
| Apoptosis | ||||
| PAWR | NM_002583 | 2.6 | 0.001 | PRKC, apoptosis, WT1, regulator |
| CASP3 | NM_004346 | 2.5 | 0.008 | Caspase 3 |
| CASP2 | AF314174 | 2.0 | 0.028 | Caspase 2 |
| Signal transduction | ||||
| PMCH | NM_002674 | 331.2 | <0.001 | Promelanin–concentrating hormone |
| PIK3CG | AF327656 | 9.9 | 0.013 | Phosphoinositide-3-kinase, catalytic, γ |
| SOCS1 | AB005043 | 5.8 | <0.001 | Suppressor of cytokine signaling 1 |
| LIFR | NM_002310 | 5.7 | <0.001 | Leukemia inhibitory factor receptor |
| BMP4 | D30751 | 3.4 | <0.001 | Bone morphogenetic protein 4 |
| CSF2RB | AV756141 | 3.2 | <0.001 | Colony stimulating factor 2 receptor β |
| KIAA0551 | AF172268 | 3.2 | <0.001 | Traf2 and NCK interacting kinase |
| RGS2 | NM_002923 | 3.1 | <0.001 | Regulator of G-protein signaling 2 |
| INHBA | M13436 | 3.0 | <0.001 | Inhibin βA |
| MET | BG170541 | 2.7 | 0.003 | Hepatocyte growth factor receptor |
| RICS | NM_014715 | 2.3 | 0.045 | Rho GTPase-activating protein |
| H11 | AF133207 | 2.2 | 0.002 | Protein kinase H11 |
| BMP2 | NM_001200 | 2.2 | <0.001 | Bone morphogenetic protein 2 |
| GUCY1B3 | W93728 | 2.1 | 0.010 | Guanylate cyclase 1, soluble, β3 |
| EXT1 | NM_000127 | 2.0 | <0.001 | Exostoses (multiple) 1 |
| ARL7 | NM_005737 | 2.0 | 0.005 | ADP-ribosylation factor-like 7 |
| Transcription factors | ||||
| CREM | D14826 | 8.5 | 0.004 | cAMP responsive element modulator |
| PKNOX2 | AK023792 | 6.2 | 0.001 | PBX/knotted 1 homeobox 2 |
| MAD | NM_002357 | 5.4 | <0.001 | MAX dimerization protein 1 |
| FOXC1 | AU145890 | 4.6 | 0.011 | Forkhead box C1 |
| CITED2 | NM_006079 | 4.2 | <0.001 | Cbp/p300-interacting transactivator |
| IRLB | BE268538 | 4.1 | <0.001 | c-Myc promoter-binding protein |
| CEBPB | AL564683 | 2.9 | <0.001 | CCAAT/enhancer binding protein β |
| POU4F1 | NM_006237 | 2.6 | 0.005 | POU domain, class 4, transcription factor 1 |
| GATA6 | D87811 | 2.3 | 0.018 | GATA binding protein 6 |
| KIAA0146 | NM_005195 | 2.3 | <0.001 | CCAAT enhancer binding protein (CEBP) |
| SSRP2 | NM_012446 | 2.2 | 0.003 | Single-stranded DNA binding protein 2 |
| ELL2 | NM_012081 | 2.1 | 0.022 | ELL-related RNA polymerase II, elongation factor |
| KLF4 | BF514079 | 2.1 | 0.011 | Kruppel-like factor 4 |
| TRAP95 | NM_005481 | 2.0 | 0.038 | Thyroid hormone receptor-associated protein, 95-kD subunit |
| CART1 | NM_006982 | 2.0 | 0.024 | Cartilage paired-class homeoprotein 1 |
| TOX | AI961231 | 2.0 | 0.009 | Thymus high mobility group box protein |
| Others | ||||
| MCHP | S64288 | 204.2 | <0.001 | Melanin-concentrating hormone precursor |
| HS3ST1 | BF000296 | 10.7 | 0.002 | Heparan sulfate 3-O-sulfotransferase 1 |
| CDC45L | NM_003504 | 7.4 | 0.003 | CDC45 cell division cycle 45-like |
| SIAT8A | L32867 | 6.5 | <0.001 | Sialyltransferase 8A |
| TMOD1 | NM_003275 | 5.9 | 0.004 | Tropomodulin 1 |
| MTHFR | AJ249275 | 5.7 | 0.009 | 5,10–Methylenetetrahydrofolate reductase |
| ENPP1 | NM_006208 | 5.2 | 0.004 | Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| LOX | NM_002317 | 5.1 | <0.001 | Lysyl oxidase |
| AMIGO4 | AC004010 | 4.2 | <0.001 | Amphoterin induced gene 2 |
| SULF1 | AW043713 | 4.6 | <0.001 | Sulfatase 1 |
| GJA5 | NM_005266 | 4.3 | <0.001 | Gap junction protein (Connexin 40) |
| ARK5 | NM_014840 | 3.9 | <0.001 | KIAA0537 gene product |
| FKBP5 | NM_004117 | 3.8 | 0.002 | FK506 binding protein 5 |
| LRRTM2 | NM_015564 | 3.8 | 0.017 | Leucine-rich repeat transmembrane neuronal 2 protein |
| COVA1 | NM_006375 | 3.6 | 0.014 | Cytosolic ovarian carcinoma antigen 1 |
| DACT1 | NM_016651 | 3.6 | <0.001 | Dapper homolog 1, antagonist of β-catenin |
| DMD | NM_004010 | 3.6 | <0.001 | Dystrophin |
| LRRN3 | AI221950 | 3.5 | 0.006 | Leucine rich repeat neuronal 3 |
| PTX3 | NM_002852 | 3.5 | <0.001 | Pentaxin-related gene |
| CLCN4 | AA071195 | 3.5 | 0.006 | Chloride channel 4 |
| SLC38A1 | NM_030674 | 3.5 | <0.001 | Amino acid transporter system A1 |
| FLJ11743 | NM_024527 | 3.5 | 0.011 | Hypothetical protein FLJ11743 |
| OSPBL11 | NM_022776 | 3.4 | <0.001 | Oxysterol binding protein-like 11 |
| CH25H | NM_003956 | 3.2 | 0.026 | Cholesterol 25-hydroxylase |
| FBN1 | AI264196 | 2.8 | 0.003 | Fibrillin 1 (Marfan syndrome) |
| ELAVL2 | NM_004432 | 2.7 | <0.001 | ELAV (embryonic lethal, abnormal vision)-like 2 |
| CPT2 | M58581 | 2.7 | 0.020 | Carnitine palmitoyltransferase II |
| NNMT | NM_006169 | 2.5 | <0.001 | Nicotinamide N-methyltransferase |
| UP | NM_003364 | 2.5 | <0.001 | Uridine phosphorylase |
| KCNK3 | NM_002246 | 2.5 | 0.022 | Potassium channel, subfamily K, member 3 |
| DAAM1 | AK021890 | 2.5 | <0.001 | Dishevelled associated activator of morphogenesis 1 |
| SLC22A4 | NM_003059 | 2.4 | <0.001 | Solute carrier family 22, member 4 |
| PSCD1 | NM_004762 | 2.4 | <0.001 | Cytohesin 1 |
| JAG1 | NM_000214 | 2.4 | 0.024 | Jagged 1 (Alagille syndrome) |
| EGLN3 | NM_022073 | 2.4 | 0.007 | Egl 9 homolog 3 |
| TPK1 | NM_022445 | 2.3 | 0.005 | Thiamin pyrophosphokinase 1 |
| LOC169611 | AL050002 | 2.3 | 0.004 | Hypothetical protein LOC169611 |
| PVRL3 | AA129716 | 2.3 | 0.004 | Poliovirus receptor-related 3 |
| DOK5 | AL050069 | 2.2 | 0.002 | Docking protein 5 |
| MRF2 | BG285011 | 2.2 | <0.001 | Modulator recognition factor 2 |
| DNAJC3 | NM_006260 | 2.2 | 0.034 | DnaJ (Hsp40) homolog, subfamily C, 3 |
| CPR8 | AK022459 | 2.2 | 0.005 | Cell cycle progression 8 protein |
| SIAT1 | AV695711 | 2.1 | 0.002 | Sialyltransferase 1 |
| RDX | NM_002906 | 2.1 | 0.024 | Radixin |
| CYP1B1 | NM_000104 | 2.0 | 0.010 | Cytochrome P450 1B1 |
| ALDH1A2 | NM_003888 | 2.0 | 0.002 | Aldehyde dehydrogenase1A2 |
| GCNT1 | NM_001490 | 2.0 | <0.001 | β-1,6-N-acetylglucosaminyltransferase |
| Unknown | ||||
| DKK2 | NM_014421 | 26.5 | <0.001 | Dickkopf homolog 2 |
| T12479 | AW029169 | 8.5 | <0.001 | Hypothetical protein DKFZp 564N1362.1 |
| FLJ10713 | NM_018189 | 5.0 | <0.001 | Hypothetical protein FLJ10713 |
| KIAA0977 | NM_014900 | 3.8 | <0.001 | KIAA0977 protein |
| LOC51334 | NM_016644 | 2.8 | 0.010 | Mesenchymal stem cell protein DSC54 |
| CGI-115 | NM_016052 | 2.6 | <0.001 | CGI-115 protein |
| C13orf7 | NM_024546 | 2.4 | <0.001 | Chromosome 13 open reading frame 7 |
| FLJ20378 | AI336206 | 2.2 | <0.001 | Hypothetical protein FLJ20378 |
| SCA1 | NM_000332 | 2.2 | 0.012 | Spinocerebellar ataxia 1 |
| FLJ90005 | W27419 | 2.1 | <0.001 | Hypothetical protein FLJ90005 |
| 24739 | AF070571 | 2.1 | 0.011 | Homo sapiens clone 24739 |
| FJX1 | NM_014344 | 2.1 | 0.007 | Four jointed box 1 |
| FLJ10901 | NM_018265 | 2.0 | 0.020 | Hypothetical protein FLJ10901 |
| HRASLS | NM_020386 | 2.0 | 0.002 | HRAS-like suppressor |
| Housekeeping genes | ||||
| ACTB | Hs.426930 | 1.0 | 0.694 | β-Actin |
| GAPDH | M33197 | 1.0 | 0.680 | Glyceraldehyde-3-phosphate dehydrogenase |