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The absence of PARP-1 prevents the AII-induced endothelial dysfunction. Acetylcholine-induced endothelium-dependent relaxations are shown. Each point of the curve represents mean ±SEM of 6 experiments in vascular rings. *P < 0.05 denotes significant loss of endothelium-dependent relaxations in the AII-treated wild-type mice, when compared with the response in vehicle-treated wild-type mice.
