Figure 1.

Adsorption of PrP^Sc is proportional to ICSM 35 concentration. Decreasing 10-fold dilutions of ICSM 35 (starting at 50 mg/mL) were adsorbed to Dynabeads as described in Materials and Methods. Next 10⁷ of these beads were added to 50 μL of a 10% RML brain homogenate spiked into an equal volume of 10% Prn-P^º/º brain homogenate. Representative of 3 experiments.