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Mouse lung histopathology. (A) Control mouse i.n. administered PBS at day 1 has normal alveoli and bronchioles and fine, delicate septa. (B) Mouse challenged with H10407 (2 × 108 bacteria) at day 1 has pneumonia with increased macrophages and neutrophils that obscure alveoli and thicken the septa (arrows). Many macrophages contain intracellular bacilli (data not shown). H&E was used for staining. Magnification, ×200.
