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. 2003 Jan;71(1):13–21. doi: 10.1128/IAI.71.1.13-21.2003

FIG. 4.

FIG. 4.

Mice were challenged with H10407 (2 × 108 bacteria) and B7A (4 × 108 bacteria), and serum was collected at days 10, 14, 21, 28, 35, and 42. Serum IgG (A), IgM (B), and IgA (C) antibody responses were measured against CFA/I, O78 LPS, and LT following i.n. challenge with H10407, and serum IgG (D) and IgM (E) antibody responses were measured against CS6, O148 LPS, and LT following i.n. challenge with B7A. No serum IgA antibody response was measured in mice challenged with B7A (data not shown). Endpoint ELISA titers were expressed as the reciprocal of the highest dilution of immune serum at which the A405 was at least twice that of the nonimmune control serum (mice administered PBS) and the A405 of the immune serum was at least 0.2. Data are presented as the mean titers (of four mice) of the IgG, IgM, and IgA antibodies. The error bars represent ±1 standard deviation of the mean response. At all titers P was <0.05 compared with the PBS control mice, except on day 10 for O148 LPS IgG (D) and days 10 and 14 for LT IgG for both H10407 (A)- and B7A (D)-challenged mice.