TABLE 1.
Strain and no. of organisms | No. of dead mice at day postchallenge:
|
Totalb | ||||||
---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | ||
H10407 | ||||||||
0c | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0/12 (0) |
1 × 108 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0/12 (0) |
5 × 108 | 0 | 3 | 1 | 2 | 1 | 0 | 0 | 7/12 (58) |
1 × 109 | 0 | 8 | 4 | 12/12 (100) | ||||
5 × 109 | 0 | 6 | 6/6 (100) | |||||
B7A | ||||||||
0c | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0/12 (0) |
1 × 108 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0/12 (0) |
5 × 108 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 3/12 (25) |
1 × 109 | 0 | 0 | 5 | 4 | 0 | 0 | 1 | 10/12 (83) |
5 × 109 | 0 | 1 | 5 | 6/6 (100) |
Mice were challenged i.n. with the bacterial dose in 50 μl of PBS diluent administered dropwise to the external nares of each mouse. The data recorded are a combination of two independent trials, except for the 5 × 109 bacterial dose.
Number of dead mice/total number of mice (percent mortality).
Control mice were administered 50 μl of PBS i.n.