TABLE 1.
Survival following i.p. inoculation of C. violaceuma
| Genotype | CFU administered per mouse | % Mortality (no. dead/total) | No. of days to deathb |
|---|---|---|---|
| Wild-type | 108 | 100 (8/8) | 1 |
| 107 | 71 (5/7) | 3, 3, 3, 7, 7 | |
| 106 | 0 (0/7) | NA | |
| 105 | 0 (0/4) | NA | |
| 104 | 0 (0/3) | NA | |
| 103 | 0 (0/3) | NA | |
| p47phax−/− | 1.5 × 103 | 100 (8/8) | ≤2 |
| 1.5 × 102 | 100 (8/8) | ≤2 | |
| 0.7 × 102 | 100 (8/8) | ≤2 | |
| 0.13 × 102 | 88 (7/8) | ≤2 | |
| iNOS−/− | 2.7 × 106 | 50 (2/4) | 16, 19 |
| 2 × 105 | 12.5 (1/8) | 26 | |
| 1.7 × 103 | 0 (0/4) | NA | |
| 1.7 × 102 | 0 (0/7) | NA |
a
Surviving mice were observed for at least 6 weeks following i.p. challenge. These data are pooled from two separate experiments which yielded similar results.
b
NA, not applicable.