TABLE 2.
Protection of BALB/cByJ mice passively immunized with anti-PspA serum
| Challenge strain | Capsule serotype | PspA serotype | No. of mice alive/ no. totalb
|
Pc | |
|---|---|---|---|---|---|
| Without antibody | With antibody | ||||
| WU2 | 3 | 1 | 0/12 | 12/12 | <0.0001 |
| MA1025 | 3 | 25 | 0/5 | 5/5 | 0.0079 |
| D39 | 2 | 25 | 4/14 | 6/14 | NS |
| MA139/MA158a | 2 | 1 | 3/14 | 6/14 | NS |
| JD803/JD804a | 3 | 25 | 6/14 | 7/14 | NS |
a
Data was combined for the two independently obtained derivatives, which did not differ from each other.
b
Mice were infected intravenously with 107 CFU 1 h after intraperitoneal immunization with anti-PspA polyclonal antiserum (with antibody) or a control antiserum lacking PspA-specific antibody (without antibody).
c
Calculated by using Fisher's exact test. NS, not significant.