Table 1.

Putative somatic mutations in cancer and normal ESTs.

EST source	Total number of substitutions (N)	Number of synonymous substitutions (Ns)	Number of non-synonymous substitutions (Na)	Number of nonsense substitutions (Nns)	Ns/Na	Nns/N	Ns exp	Na exp	Nns exp	Ns/Na exp	Nns/N exp	p_value χ2 Ns/Na observed vs expected	p_value χ2 Nns/N observed vs expected
Normal	429070	131244	286416	11410	0.46	0.027	111827	301723	15521	0.37	0.036	<10-10	<10-10
Cancer	253254	74090	172551	6613	0.43	0.026	64719	179818	8717	0.36	0.034	<10-10	<10-10