Table 3.

Correlation of thermodynamic stability difference of the 5'/3' ends of siRNA duplexes with siRNA activity (AS) and with the ratio between the antisense strand and sense strand activities (AS/SS). Differences in the stability of the 5' and 3' ends were calculated for 2 (Diff2), 3 (Diff3), 4 (Diff4) and 5 (Diff5) terminal nucleotides in siRNA duplexes.

Data set	Activity or ratio	Correlation coefficients				Reference
		Diff2	Diff3	Diff4	Diff5
28 siRNAs	AS	-0.245	-0.196	-0.171	-0.103	Hu et al. [11]
28 siRNAs	AS/SS	-0.384	-0.356	-0.368	-0.278	Hu et al. [11]
18 siRNAs	AS	-0.870	-0.869	-0.748	-0.767	Schwartz et al. [3]
18 siRNAs	AS/SS	-0.629	-0.544	-0.471	-0.453	Schwartz et al. [3]
653 siRNAs	AS	-0.356	-0.332	-0.292	-0.228	This work