Table 1.

Host drug targets that have antiviral activity

Virus family	Virus species	Host-cell target	Drug	Antiviral activity in vitro	Antiviral activity in vivo	References
Poxviridae	Vaccinia virus	Abl tyrosine kinase	Gleevec	+	+	[13]
Herpesviridae	KSHV	c-Kit	Gleevec	+	+	[14,21]
	KSHV	Vitamin D receptor	Vitamin D analog EB1089	+	-	[16]
	HSV-1	EIF-2α	Salubrinal	+	-	[30]
	HCMV	COX-2	BMS-279652	+	-	[15,23]
			BMS-279654
			BMS-279655
			Indomethacin
			Aspirin
Unclassified	Hepatitis D virus	Farnesyltransferase	FTI-277	+	+	[18,19]
			FTI-2153
Hepadnaviridae	Hepatitis B virus	Heterogeneous nuclear ribonucleoprotein K (hnRNP K)	siRNA	+	-	[31]
Retroviridae	HIV	HMG-CoA reductase	Lovastatin	+	+	[17]
	HIV	Geranylgeranyltransferase I	GGTI-286	+	-	[17]
	HIV	ATM kinase	KU-55933	+	-	[28]
	HIV	Deoxyhypusine synthase	CNI-1493	+	-	[29]
	HIV	Histone deacetylase	Valporic acid	+	+	[32,33]
Flaviviridae	West Nile disease virus	c-Yes (Src family kinases)	PP2 SU6656	+	-	[20]