Table 2.
P. falciparum gene families encoding exported proteins
| Family | Paralogs | Transmembrane domains | Exons | Microarray data | Comments | |||||
| R | T | S | M | Sp | G | |||||
| PfEMP1 | 59 | 1 | 2 | x | x | x | x | x | x | |
| DnaJ I | 3 | 0 | 1/4/5 | 1 | 0 | 0 | 1 | 0 | 0 | DnaJ domains 1-3 |
| DnaJ III | 16 | 0/1 | 2 | 3 | 1 | 1 | 3 | 0 | 0 | DnaJ domain 1 |
| EMP3 | 2 | 0 | 2 | 2 | 2 | 1 | 2 | 1 | 0 | MC proteins |
| GBP130 | 3 | 0 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | RBC surface proteins |
| FIKK kinases | 20 | 0 | 3 | 4 | 4 | 0 | 4 | 0 | 0 | Protein kinase domain |
| PfMC-2TM | 10 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | MC proteins |
| RIFIN | 160 | 2 | 2 | 3 | 6 | 2 | 2 | 1 | 0 | RBC surface proteins |
| STEVOR | 30 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | MC proteins |
| a/b_HYDa | 4 | 1 × 2, 2 × 1 | 1 × 1, 1 × 7, 2 × 2 | 0 | 0 | 0 | 0 | 0 | 0 | a/b hydrolases |
| a/b_HYDb | 4 | 0 | 2 × 1, 2 × 2 | 0 | 1 | 1 | 0 | 0 | 0 | a/b hydrolases |
| HYP1 | 2 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | |
| HYP2 | 3 | 1 × 2, 2 × 0 | 1 × 1, 2 × 2 | 0 | 0 | 0 | 0 | 0 | 0 | Probably not a real family |
| PHISTa | 23 | 0 | 2/3 | 2 | 1 | 2 | 2 | 1 | 1 | Four alpha helices |
| PHISTb | 23 | 0 | 2 | 13 | 10 | 6 | 6 | 2 | 3 | Four alpha helices |
| PHISTc | 16 | 0 | 2 | 9 | 4 | 2 | 7 | 1 | 0 | Four alpha helices conserved |
| HYP4 | 8 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | Similar to HYP6 |
| HYP5 | 7 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| HYP6 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| HYP7 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | Similar to HYP8 |
| HYP8 | 2 | 2 | 2 | 2 | 1 | 0 | 2 | 0 | 0 | Proteomics iRBC localisation |
| HYP9 | 5 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | |
| HYP10 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | May be GPI anchored |
| HYP11 | 5 | 0 | 2 × 1, 3 × 2 | 0 | 1 | 0 | 0 | 0 | 0 | Similar to PHIST |
| HYP12 | 3 | 0 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | |
| HYP13 | 2 | 2 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | Similar to HYP5 |
| HYP15 | 4 | 2 | 2 × 1, 2 × 2 | 0 | 0 | 0 | 1 | 0 | 0 | Similar to HYP5 |
| HYP16 | 2 | 1 × 1, 1 × 2 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | Conserved |
| HYP17 | 2 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | |
Approximately 75% of all 396 P. falciparum proteins predicted to be exported are organised in families. Counts in columns 5 to 10 represent the number of family members deemed to be expressed by this method for each life cycle stage (except PfEMP1). Abbreviations for life cycle stages in the microarray section are: R, ring; T, trophozoite; S, schizont; M, merozoite; Sp, sporozoite; G, gametocyte. GPI, glycosylphosphatidyl inositol; iRBC, infected red blood cell; MC, Maurer's clefts; RBC, red blood cell.